Promiscuous Methionyl-tRNA Synthetase Mediates Adaptive Mistranslation against Oxidative Stresses
نویسندگان
چکیده
Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul 151-742, Korea. Research Institute of Pharmaceutical Sciences, Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 151-742, Korea. Department of Molecular Bioscience, Kang Won National University, Chuncheon-si, Gangwon-do, 200-701, Korea. School of Life Science and Biotechnology, Kyungpook National University, Daegu, 702-701, Korea. Department of Computer Science and Engineering Center for Computer Graphics and Virtual Reality, Ewha Womans University, Seoul 120-750, Korea. WCU Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Suwon 443-270, Korea.
منابع مشابه
Promiscuous methionyl-tRNA synthetase mediates adaptive mistranslation to protect cells against oxidative stress
Aminoacyl-tRNA synthetases (ARSs) acylate transfer (t)RNAs with amino acids. Charging tRNAs with the right amino acids is the first step in translation; therefore, the accurate and error-free functioning of ARSs is an essential prerequisite for translational fidelity. A recent study found that methionine (Met) can be incorporated into non-Met residues of proteins through methionylation of non-c...
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تاریخ انتشار 2014